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TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

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Exposure to ionizing radiation is well known to promote oxygen radical formation within biological systems through radiolysis (interaction of radiation and water).12 Hypoxia or/and hyperoxia condition in cells has been noted to generate numerous oxygen-derived radicals.13 Besides, a couple of therapeutic drugs such as acetaminophen have been reported to cause oxidizing effects on cells, consequently leading to formation of oxygen radicals through the activity of drug metabolizing enzymes known as cytochrome P -450 system.14 5